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Bioorg Med Chem. 2002 Jul;10(7):2193-8.

Synthesis and anti-tubercular evaluation of 4-quinolylhydrazones.

Author information

1
Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via A. Moro, 53100 Siena, Italy. savini@unisi.it

Abstract

A series of 4-quinolylhydrazones were synthesized and tested against Mycobacterium tuberculosis H37Rv. Preparation of the title compounds was achieved by reaction of 4-quinolylhydrazine and aryl- or heteroaryl-carboxaldehyde. For the most of derivatives interesting antitubercular properties were showed; two compounds (3(2) and 3(25)), identified as the most active, were tested also against Mycobacterium avium.

PMID:
11983516
DOI:
10.1016/s0968-0896(02)00071-8
[Indexed for MEDLINE]

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