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J Hepatol. 2002 May;36(5):586-9.

Natural history and outcome in 32 Swedish patients with small duct primary sclerosing cholangitis (PSC).

Author information

1
Department of Gastroenterology, Huddinge University Hospital, Stockholm, Sweden. ulrika.broome@medhs.ki.se

Abstract

BACKGROUND/AIMS:

This study aims at describing the natural history and outcome of small duct primary sclerosing cholangitis (PSC).

METHODS:

Thirty-two patients with small duct PSC were studied. The average time taken for diagnosis was 69 (1-168) months. The median follow-up time was 63 (1-194) months.

RESULTS:

All patients including one who underwent liver transplantation because of end-stage liver disease and hepatocellular carcinoma were alive at follow-up. None developed cholangiocarcinoma. In 27 patients repeated cholangiographic examinations were done after a median time of 72 (12-192) months from first ERCP. Four developed features of large duct PSC.

CONCLUSIONS:

Small duct PSC rarely progresses to large bile duct PSC and it seems to have a benign course in most patients and no development of cholangiocarcinoma was found.

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PMID:
11983440
[Indexed for MEDLINE]

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