Format

Send to

Choose Destination
Cell. 2002 Apr;109 Suppl:S45-55.

The mechanism and regulation of chromosomal V(D)J recombination.

Author information

1
Howard Hughes Medical Institute, The Children's Hospital, The Center for Blood Research, Boston, MA 02115, USA.

Abstract

V(D)J recombination is of fundamental importance to the generation of diverse antigen receptor repertoires. We review our current understanding of the V(D)J recombination reaction and how it is regulated during lymphocyte development. We also discuss how defects in the mechanism or regulation of V(D)J recombination can lead to human disease.

PMID:
11983152
DOI:
10.1016/s0092-8674(02)00675-x
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center