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J Biochem. 2002 May;131(5):629-33.

Diacylglycerol kinases: emerging downstream regulators in cell signaling systems.

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  • 1Department of Biochemistry, School of Medicine, Sapporo Medical University, South-West-17, Sapporo 060-8556, Japan.


Diacylglycerol kinase (DGK) regulates signal transduction by modulating the balance between the two signaling lipids, diacylglycerol and phosphatidic acid. DGK and its homologs occur in a wide range of multicellular organisms and the mammalian DGK is known to consist of nine members with a considerable incidence of alternative splicing. Recent work has established that DGK serves as a key attenuator of diacylglycerol of signaling functions and that the mammalian isozymes are equipped with molecular machineries which enable them to act in specific intracellular sites and/or in signaling protein complexes.

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