Format

Send to

Choose Destination
See comment in PubMed Commons below
Kidney Int Suppl. 2002 May;(80):23-6.

New approaches to delay the progression of chronic renal failure.

Author information

1
of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110-1092, USA. sklahr@im.wustl.edu

Abstract

BACKGROUND:

The molecular cloning of many bone morphogenetic proteins (BMP)-encoding genes and their identification as transforming growth factor-beta (TGF-beta) relatives enhanced the interest in these molecules and allowed expression and functional studies to be performed.

METHODS:

Rats with ureteral obstruction were distributed into four groups. Group 1 received vehicle, group 2 received enalapril 12.5 mg/kg body wt/day, group 3 received 50 or 300 microg/kg body wt BMP-7, and group 4 received both enalapril and the high dose of BMP-7. We also studied the effects of BMP-7 administration in a model streptozocin-induced diabetes.

RESULTS:

Treatment with BMP-7 in rats with ureteral obstruction of 3 days duration and subsequent release indicated that this compound decreases interstitial volume and accelerates the return of renal function. After 16 weeks of diabetes, the rats were treated with BMP-7. The administration of BMP-7 partially reversed renal hypertrophy, restored GFR to normal, and decreased proteinuria.

CONCLUSIONS:

These studies indicate that administration of BMP-7 maintains and restores renal function and structure in animals with ureteral obstruction and diabetic nephropathy.

PMID:
11982808
DOI:
10.1046/j.1523-1755.61.s80.16.x
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center