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Clin Exp Immunol. 2002 Apr;128(1):21-6.

Leptin inhibits stress-induced apoptosis of T lymphocytes.

Author information

1
Department of Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. s75@kuhp.kyoto-u.ac.jp

Abstract

Leptin, which is secreted by adipocytes, the placenta and the stomach, not only controls appetite through leptin receptors in the hypothalamus but also regulates cell-mediated immunity. In this study we have demonstrated that continuous injection of leptin prevents the reduction in lymphocyte numbers normally observed in fasted and steroid-injected mice. Consistent with leptin-induced protection, we observed up-regulation of the bcl-xL gene as a result of signal transduction via leptin receptors on lymphocytes. We suggest that leptin might contribute to the recovery of immune suppression in malnourished mice by inhibiting lymphocyte apoptosis.

PMID:
11982586
PMCID:
PMC1906378
DOI:
10.1046/j.1365-2249.2002.01797.x
[Indexed for MEDLINE]
Free PMC Article

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