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Methods Find Exp Clin Pharmacol. 2002 Jan-Feb;24(1):19-21.

Behavioral effect of herbal glycoside in the forced swimming test.

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Psychosomatic Division, Akita University School of Medicine, Akita, Japan.


We investigated the behavioral effects of Chinese herbal medicines in the forced swimming test. One of these medicines, Kami-shoyo-san, induced an antidepressive climbing behavior in mice. An effective substance detected to be an O-linked glycoside with the sugar chain structure GalNAc alpha 1-3GalNAc was separated. The behavioral effect was dose-dependently decreased by the dopamine 2 antagonist sulpiride, but not by the dopamine 1 antagonist SCH-233960. Investigated Chinese herbal medicines, including Kami-shoyo-san, have been used for human depression. These facts suggest that glycoside is one of the antidepressant-like substances of Chinese herbal medicines.

[Indexed for MEDLINE]

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