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Trends Cell Biol. 2002 Apr;12(4):193-200.

Protein kinase D: an intracellular traffic regulator on the move.

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Division of Biochemistry, Faculty of Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000, Leuven, Belgium.


Recent research has identified protein kinase D (PKD, also called PKCmu) as a serine/threonine kinase with potentially important roles in growth factor signaling as well as in stress-induced signaling. Moreover, PKD has emerged as an important regulator of plasma membrane enzymes and receptors, in some cases mediating cross-talk between different signaling systems. The recent discovery of two additional kinases belonging to the PKD family and the plethora of proteins that interact with PKD point to a multifaceted regulation and a multifunctional role for these enzymes, with functions in processes as diverse as cell proliferation, apoptosis, immune cell regulation, tumor cell invasion and regulation of Golgi vesicle fission.

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