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Int J Antimicrob Agents. 2002 Apr;19(4):261-8.

Animal model pharmacokinetics and pharmacodynamics: a critical review.

Author information

1
University of Wisconsin, 600 Highland Avenue, Room H4/572, Madison,USA. dra@medicine.wisc.edu

Abstract

Animals have been extensively used in the evaluation of antimicrobials. The value of animals in the pharmacokinetic and pharmacodynamic characterization of antimicrobials is critically reviewed. Animal studies have demonstrated that the pharmacokinetic/pharmacodynamic (PK/PD) target determining efficacy can vary for different classes of antimicrobials. However, the magnitude of the target required for bacteriological efficacy is relatively similar for various sites of infection, various pathogens and various drugs within the same class, provided free drug levels are used.

PMID:
11978497
[Indexed for MEDLINE]

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