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Trends Microbiol. 2002 May;10(5):203-5.

Tsg101: HIV-1's ticket to ride.

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Department of Molecular Genetics & Microbiology, Life Sciences Bldg, SUNY at Stony Brook, Stony Brook, NY 11794-5222, USA.


Recent studies implicate the vacuolar protein-sorting pathway in the transport of the retroviral structural precursor (Gag) protein to its budding site on the plasma membrane of infected cells. This exploitation of the cellular endocytic trafficking machinery to release viral particles could lead to the identification of virus-specific modulators and provide opportunities to design new targeted anti-viral agents.

[Indexed for MEDLINE]

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