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Curr Opin Immunol. 2002 Jun;14(3):360-5.

Influence of effector molecules on the CD8(+) T cell response to infection.

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1
Department of Microbiology, and Interdisciplinary Graduate Program in Immunology, University of Iowa, 3-512 Bowen Science Building, 51 Newton Road, Iowa City, IA 52242, USA.

Abstract

Expansion and contraction of antigen-specific CD8(+) T cells after infection or vaccination results in stable memory. Recent evidence demonstrates that anti-microbial effector molecules such as perforin and IFN-gamma regulate specific aspects of CD8(+) T cell homeostasis by mechanisms that may be dependent or independent of pathogen clearance.

PMID:
11973135
[Indexed for MEDLINE]
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