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Nat Rev Genet. 2002 Mar;3(3):176-88.

The art and design of genetic screens: Drosophila melanogaster.

Author information

1
Wellcome/CRC Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK. ds139@mole.bio.cam.ac.uk

Abstract

The success of Drosophila melanogaster as a model organism is largely due to the power of forward genetic screens to identify the genes that are involved in a biological process. Traditional screens, such as the Nobel-prize-winning screen for embryonic-patterning mutants, can only identify the earliest phenotype of a mutation. This review describes the ingenious approaches that have been devised to circumvent this problem: modifier screens, for example, have been invaluable for elucidating signal-transduction pathways, whereas clonal screens now make it possible to screen for almost any phenotype in any cell at any stage of development.

PMID:
11972155
DOI:
10.1038/nrg751
[Indexed for MEDLINE]

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