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J Pediatr Hematol Oncol. 2002 May;24(4):321-2.

Interaction between methotrexate and ciprofloxacin.

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Unite d'Onco-Hematologie Pediatrique, Hopital Jeanne de Flandre, Lille, France.


High-dose methotrexate is used in malignant hemopathies and solid tumors in children. Methotrexate serum concentrations must be monitored because of the possible toxicity of drug elimination delay. Several drugs (e.g., penicillin, probenecid) can alter the elimination of methotrexate. The authors report two cases of delayed elimination of methotrexate in patients receiving ciprofloxacin, with severe toxicity.

[Indexed for MEDLINE]

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