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Dev Cell. 2002 Apr;2(4):389-406.

Reaching a genetic and molecular understanding of skeletal development.

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Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.


In the last ten years, we have made considerable progress in our genetic and molecular understanding of all aspects of skeletal development, chondrogenesis, joint formation, and osteogenesis. This review addresses the role of the principal growth factors and transcription factors affecting these different processes and presents, in several cases, the genetic cascade leading to cell differentiation.

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