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Dev Cell. 2002 Apr;2(4):385-7.

Protein tyrosine phosphatase 1B: a potential leptin resistance factor of obesity.

Author information

1
Gifford Laboratories, Touchstone Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Abstract

Indirect evidence implicates leptin resistance in the pathogenesis of the lipotoxicity that complicates obesity and results in the metabolic syndrome. In this issue of Developmental Cell, two groups identify protein tyrosine phosphatase 1B (PTP1B) as a cause of leptin resistance through dephosphorylation of Jak2.

PMID:
11970889
DOI:
10.1016/s1534-5807(02)00158-2
[Indexed for MEDLINE]
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