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Immunity. 2002 Apr;16(4):493-7.

Live and let die: Nef functions beyond HIV replication.

Author information

1
Department of Virology, University of Heidelberg, D-69120 Heidelberg, Germany.

Abstract

The viral Nef protein is important for the progression of the human and simian immunodeficiency virus (HIV/SIV) infection. So far, experimental evidence has suggested that Nef enhances viral replication and infectivity through a combination of different effects. Recent insights, however, indicate that its functions are more complex than previously anticipated. By targeting the T cell receptor, Nef may not only prime viral replication but, more importantly, ensure viral survival through distinct mechanisms of immune evasion and antiapoptosis.

PMID:
11970873
DOI:
10.1016/s1074-7613(02)00307-2
[Indexed for MEDLINE]
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