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Bioorg Med Chem Lett. 2002 May 6;12(9):1287-9.

Imidazole-based ligands of the Src SH2 protein.

Author information

1
Aventis Pharma, Paris Research Center, Medicinal Chemistry, 102 route de Noisy, 93235 Cedex, Romainville, France. pierre.deprez@aventis.com

Abstract

Starting from known Src SH2 inhibitors incorporating five-membered heterocycles or benzamide scaffolds, we prepared tetrasubstituted imidazole compounds able to interact with the pY, pY+1 and pY+3 binding sites of the Src SH2 protein. The synthesis and biological data are presented.

PMID:
11965372
DOI:
10.1016/s0960-894x(02)00138-5
[Indexed for MEDLINE]

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