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Curr Opin Infect Dis. 2001 Jun;14(3):273-7.

The role of the neutrophil and phagocytosis in infection caused by Helicobacter pylori.

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Department of Medicine, Division of Infectious Diseases, and the Inflammation Program, University of Iowa and the Veterans Affairs Medical Center, Iowa City, Iowa 52242, USA.


Recent advances in our understanding of Helicobacter pylori-phagocyte interactions indicate that these organisms actively modulate phagocyte function in order to retard phagocytosis, while simultaneously inducing a strong respiratory burst. The central players in this dynamic include H. pylori neutrophil activating protein and factors that are associated with the cag pathogenicity island type IV secretion apparatus. Additionally, catalase, alkyl hydroperoxide reductase, and factors that are unique to type I strains allow bacteria to resist phagocytic killing.

[Indexed for MEDLINE]

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