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Cell Mol Life Sci. 2002 Mar;59(3):392-402.

Bacillus subtilis sporulation and stationary phase gene expression.

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Department of Oral and Craniofacial Biological Sciences, Dental School, University of Maryland, Baltimore 21201, USA.


Bacillus subtilis cells entering stationary phase due to nutrient deprivation have a number of options. Complex interconnected regulatory circuits govern differential gene expression patterns that channel the cell along the path it has sensed is most advantageous for survival in the environment. The actual choice depends upon the activity of an elaborate signal transduction network (the phosphorelay) that ultimately affects the activity of two key transcription factors, SpoOA and AbrB. Should the cell commit to sporulation, a temporally and spatially controlled cascade of RNA polymerase sigma factors leads to the development and release of an endospore from within the terminally differentiated, apoptotic mother cell.

[Indexed for MEDLINE]

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