Mice deficient in fractalkine are less susceptible to cerebral ischemia-reperfusion injury

J Neuroimmunol. 2002 Apr;125(1-2):59-65. doi: 10.1016/s0165-5728(02)00033-4.

Abstract

Fractalkine (FKN), also known as neurotactin, is a CX(3)C chemokine that exists in both secreted and neuronal membrane-bound forms and is upregulated during brain inflammation. There is accumulating evidence that FKN induces chemotaxis by binding to its receptor CX(3)CR1 on leukocytes and microglia. We generated FKN-deficient mice to study the role of FKN in postischemic brain injury. After transient focal cerebral ischemia, FKN-deficient mice had a 28% reduction in infarction size and lower mortality rate, when compared to wild-type littermates. The findings of this study indicate a possible role for FKN in augmenting postischemic injury and mortality after transient focal cerebral ischemia.

MeSH terms

  • Animals
  • Chemokine CX3CL1
  • Chemokines, CX3C / deficiency
  • Chemokines, CX3C / genetics*
  • Chemokines, CX3C / immunology*
  • Disease Susceptibility / immunology
  • Gene Expression / immunology
  • Infarction, Middle Cerebral Artery / immunology
  • Infarction, Middle Cerebral Artery / pathology
  • Ischemic Attack, Transient / immunology*
  • Ischemic Attack, Transient / pathology
  • Membrane Proteins / deficiency
  • Membrane Proteins / genetics*
  • Membrane Proteins / immunology*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Knockout
  • RNA, Messenger / analysis
  • Reperfusion Injury / immunology*
  • Reperfusion Injury / pathology

Substances

  • Chemokine CX3CL1
  • Chemokines, CX3C
  • Cx3cl1 protein, mouse
  • Membrane Proteins
  • RNA, Messenger