Format

Send to

Choose Destination
J Neuroimmunol. 2002 Apr;125(1-2):59-65.

Mice deficient in fractalkine are less susceptible to cerebral ischemia-reperfusion injury.

Author information

1
Department of Anesthesia, Children's Hospital, Boston, 300 Longwood Avenue, Boston, MA 02115, USA. sulpicio.soriano@tch.harvard.edu

Abstract

Fractalkine (FKN), also known as neurotactin, is a CX(3)C chemokine that exists in both secreted and neuronal membrane-bound forms and is upregulated during brain inflammation. There is accumulating evidence that FKN induces chemotaxis by binding to its receptor CX(3)CR1 on leukocytes and microglia. We generated FKN-deficient mice to study the role of FKN in postischemic brain injury. After transient focal cerebral ischemia, FKN-deficient mice had a 28% reduction in infarction size and lower mortality rate, when compared to wild-type littermates. The findings of this study indicate a possible role for FKN in augmenting postischemic injury and mortality after transient focal cerebral ischemia.

PMID:
11960641
DOI:
10.1016/s0165-5728(02)00033-4
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center