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Curr Opin Struct Biol. 2002 Apr;12(2):263-9.

Deriving folds of macromolecular complexes through electron cryomicroscopy and bioinformatics approaches.

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Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA.


Intermediate-resolution (7-9A) structures of large macromolecular complexes can be obtained by electron cryomicroscopy. This structural information, combined with bioinformatics data for the individual protein components or domains, can lead to a fold model for the entire complex. Such approaches have been demonstrated with the 6.8 A structure of the rice dwarf virus to derive models for the major capsid shell proteins.

[Indexed for MEDLINE]

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