Format

Send to

Choose Destination
See comment in PubMed Commons below
FEBS Lett. 2002 Apr 10;516(1-3):87-92.

Differentiation of single-cell organisms according to elongation stages crucial for gene expression efficacy.

Author information

  • 1Laboratory of Molecular Evolution, Institute of Cytology and Genetics, Prospekt Lavrentieva 10, 630090, Novosibirsk, Russia. likho@bionet.nsc.ru

Abstract

We analyzed the interrelation between the efficiency of a gene expression and the nucleotide composition of all protein-coding sequences in 38 unicellular organisms whose complete genomic sequences are known. These organisms comprise 37 prokaryotic (29 eubacteria and eight archaebacteria) and one eukaryotic (yeast) species. We demonstrated that frequency analysis of gene codon composition fails to reflect adequately the gene expression efficiency of all these organisms. We constructed a measure, the elongation efficiency index, that considers simultaneously the information on codon frequencies and the degree of mRNA local self-complementarity. This measure recognizes the ribosome-coding genes as highly expressed in all the unicellular organisms studied. According to our analysis, these species fall into five groups differentiated by the process that makes the key contribution to the elongation rate.

PMID:
11959109
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center