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Bioorg Med Chem Lett. 2002 Mar 25;12(6):853-6.

Synthesis and photochemical protein crosslinking studies of hydrophilic naphthalimides.

Author information

1
Department of Chemistry & Biochemistry and Center for Drug Discovery, Baylor University, 76798-7348, Waco, TX, USA

Abstract

A mixture of 4-alkylamino-1,8-naphthalimides has previously been reported to exhibit potential utility as a photochemical tissue-bonding reagent. In order to determine which constituents of the mixture were responsible for the observed tissue bonding and to facilitate study of the mechanism, we have synthesized each of the primary constituents of the mixture. Each naphthalimide synthesized has been demonstrated to photochemically crosslink proteins.

PMID:
11958978
DOI:
10.1016/s0960-894x(02)00050-1
[Indexed for MEDLINE]

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