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Neurosci Lett. 2002 Apr 5;322(2):83-6.

The tau H1 haplotype is associated with Parkinson's disease in the Norwegian population.

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Laboratory of Familial Movement Disorders, Mayo Clinic, Jacksonville, FL, USA.


We investigated the association of Parkinson's disease (PD) with tau gene H1 haplotypes in the Norwegian population. In a sample of 96 unrelated PD cases and 68 control subjects, we observed an increased risk of PD for persons with the tau H1 haplotype (odds ratio=5.52; 95% confidence interval: 2.64-11.10; P=2.17x10(-6)). Findings provide evidence that tau participates in the PD pathogenic process and demonstrate the value of isolated populations in mapping complex traits.

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