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J Neuroimmunol. 2002 Mar;124(1-2):54-61.

Social disruption-induced glucocorticoid resistance: kinetics and site specificity.

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Section of Oral Biology, The Ohio State University Health Sciences Center, Columbus, OH 43218, USA.


Social disruption (SDR) of male mice has been shown to induce a state of functional glucocorticoid (GC) resistance in splenocytes. The present study demonstrated that GC resistance developed following repeated, but not acute exposure to SDR. GC resistance was long-lasting and persisted for at least 10 days after stress. In contrast, SDR did not alter cytokine secretion from peritoneal mononuclear cells treated with corticosterone. These findings suggest that SDR-induced GC resistance may be restricted to specific sites such as the spleen.

[Indexed for MEDLINE]

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