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Eur J Clin Microbiol Infect Dis. 2002 Mar;21(3):212-4. Epub 2002 Mar 19.

Cerebrospinal fluid penetration and pharmacokinetic/pharmacodynamic parameters of intravenously administered colistin in a case of multidrug-resistant Acinetobacter baumannii meningitis.

Author information

1
Service of Infectious Diseases, University Hospital Virgen del Rocío, Avenida Manuel Siurot s/n, 41013 Seville, Spain. mmejias@cica.es

Abstract

Described here is a case of meningitis caused by multidrug-resistant Acinetobacter baumannii susceptible only to colistin, which was treated successfully with intravenous colistin sulfomethate sodium (5 mg/kg/day). The levels of colistin in serum and cerebrospinal fluid and the pharmacokinetic/pharmacodynamic parameters of colistin were determined. In this case, intravenously administered colistin penetrated cerebrospinal fluid (25% of serum levels) at levels sustaining bactericidal concentrations.

PMID:
11957024
DOI:
10.1007/s10096-001-0680-2
[Indexed for MEDLINE]

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