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Virchows Arch. 2002 Apr;440(4):367-75. Epub 2001 Nov 23.

Different roles of p53 between Epstein-Barr virus-positive and -negative gastric carcinomas of matched histology.

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1
Department of Pathology, Shiga University of Medical Science, Seta-Tsukinowa-cho, Ohtsu, Shiga, 520-2192, Japan. mori@belle.shiga-med.ac.jp

Abstract

To clarify the role of p53 in the development of Epstein-Barr virus (EBV)-associated gastric carcinoma, we examined DNA-ploidy pattern, the immunoreactivity of p53, p21(WAF1) and Ki-67 and the incidence of mitosis and apoptosis in EBV-positive and -negative gastric carcinomas of similar histology: a lace pattern and/or gastric carcinoma with lymphoid stroma. There was no significant difference in DNA-ploidy pattern, Ki-67 index or frequencies of mitosis and apoptosis between the two groups. In deeply invasive tumours (involving the muscularis propria or deeper), p53-positive ones were rare in the EBV-encoded small RNA (EBER)-positive group and very common in the EBER-negative group, while in superficial tumours, around one-half of them were p53-positive in both groups. In p53-positive superficial tumours, p21(WAF1)-positive ones accounted for 80% in the EBER-positive group and were scarce in the EBER-negative group. It is thus possible that p53 immunoreactivity reflects the overexpression of wild-type p53 and the stabilization of mutant p53 in the EBER-positive and -negative groups, respectively. The role of p53 in tumour development seems to be smaller in EBER-positive than in -negative gastric carcinomas.

PMID:
11956816
DOI:
10.1007/s00428-001-0566-9
[Indexed for MEDLINE]
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