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Cell. 2002 Apr 5;109(1):1-4.

Does artemis end the hunt for the hairpin-opening activity in V(D)J recombination?

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  • 1Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA. mss@uclink4.berkeley.edu

Abstract

When complexed with the catalytic subunit of DNA-dependent protein kinase (DNA-PK(cs)), the recently discovered dsDNA break repair protein named Artemis acquires the ability to open hairpin DNA molecules in vitro. Both genetic and biochemical data point toward a physiological role for this complex as the elusive hairpin-opening activity in V(D)J recombination.

PMID:
11955439
[PubMed - indexed for MEDLINE]
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