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Clin Rheumatol. 2002 Feb;21(1):43-5.

Effects of cisapride on oesophageal transit of solids in patients with progressive systemic sclerosis.

Author information

1
Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan. sjwang@vhgtc.vghtc.gov.tw

Abstract

In most patients with progressive systemic sclerosis (PSS) the oesophagus is affected. Reflux symptoms are most frequent, whilst dysphagia also occurs. Cisapride, a prokinetic agent, may enhance motility along the gastrointestinal tract. The effects of cisapride on oesophageal transit were evaluated in 12 PSS patient using a solid-phase radionuclide oesophageal transit study. Each PSS patient was given cisapride 10 mg or placebo orally three times a day in a random, double-blind, crossover fashion. The results show that cisapride does not seem to have any impact on oesophageal transit in patients with PSS.

PMID:
11954884
[Indexed for MEDLINE]

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