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J Ren Nutr. 2002 Apr;12(2):96-101.

Severe dietary protein restriction in overt diabetic nephropathy: benefits or risks?

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1
O.U. Nephrology and Dialysis, S. Eugenio Hospital, Rome, Italy.

Abstract

OBJECTIVE:

To evaluate whether restricting protein intake may delay the progression of chronic renal failure caused by overt diabetic nephropathy and also whether this increases the risk of malnutrition.

DESIGN:

Prospective clinical trial.

SETTING:

Nephrology outpatients.

PATIENTS:

Sixty-nine patients (32 affected by type 1 and 37 by type 2 diabetes, all treated with insulin) affected by both overt diabetic nephropathy and hypertension.

INTERVENTION:

The study was started once hypertension and glycemia had been under control for at least 3 months. Two groups of patients, matched for similar mean glomerular filtration rate value and nutritional status, were studied: a low-protein diet (0.6 g/kg/d) was randomly prescribed to 35 patients, whereas in the other 34 patients a free diet intake was maintained for 12 months.

MAIN OUTCOME MEASURE:

Renal function and nutritional status.

RESULTS:

The protein intake was significantly different in the 2 groups of patients, whereas the average decline of glomerular filtration rate during the follow-up was comparable. In the low-protein diet group, serum prealbumin concentration significantly decreased after 9 months, whereas serum albumin decreased at the end of the study.

CONCLUSION:

Severe dietary protein restriction does not seem to delay the progression of renal disease in patients with overt diabetic nephropathy, whereas it may induce malnutrition.

PMID:
11953922
[Indexed for MEDLINE]
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