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Epilepsia. 2002 Apr;43(4):358-61.

Acetoacetate, acetone, and dibenzylamine (a contaminant in l-(+)-beta-hydroxybutyrate) exhibit direct anticonvulsant actions in vivo.

Author information

1
Department of Pediatrics, ZC 4482, University of California at Irvine Medical Center, Bldg. 2, 3rd Floor, 101 The City Drive S., Orange, CA 92868, USA. jmrho@uci.edu

Abstract

PURPOSE:

To investigate whether ketone bodies are directly anticonvulsant.

METHODS:

We tested the effects of acetoacetate (ACA), acetone, and both stereoisomers, D-(-)- and L-(+), of beta-hydroxybutyrate (BHB) on sensory-evoked seizures in Frings audiogenic seizure-susceptible mice.

RESULTS:

We found that these ketone bodies, with the exception of the D-(-)-isomer of BHB, were anticonvulsant in this model. Furthermore, with gas chromatography-mass spectrometry, we confirmed that the activity of L-(+)-BHB was due to dibenzylamine, a chemical contaminant.

CONCLUSIONS:

Our data indicate that the anticonvulsant efficacy of the ketogenic diet may be due in part to the direct actions of ACA and acetone.

PMID:
11952765
[Indexed for MEDLINE]
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