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Cytopathology. 2002 Apr;13(2):116-20.

Cytology of collagenous spherulosis of the breast: a diagnostic dilemma--report of three cases.

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Department of Pathology, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi 110003, India.


Collagenous spherulosis is a rare incidental finding seen in association with benign breast lesions. Cytological findings in three cases of collagenous spherulosis diagnosed on fine needle aspiration are presented. The presence of hyaline pink globules surrounded by benign myoepithelial cells in Giemsa stained smears was a diagnostic feature. Associated lesions were atypical papillary hyperplasia (2) and fibroadenoma (1). Adenoid cystic carcinoma was the close differential diagnosis on cytology. Awareness of this entity is important to avoid a false positive diagnosis of malignancy.

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