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Nat Cell Biol. 2002 May;4(5):337-42.

Par-1 regulates stability of the posterior determinant Oskar by phosphorylation.

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European Molecular Biology Laboratory, Meyerhofstrasse 1, Postfach 10.2209, D-69012 Heidelberg, Germany.


Par-1 kinase is critical for polarization of the Drosophila melanogaster oocyte and the one-cell Caenorhabditis elegans embryo. Although Par-1 localizes specifically to the posterior pole in both cells, neither its targets nor its function at the posterior pole have been elucidated. Here we show that Drosophila Par-1 phosphorylates the posterior determinant Oskar (Osk) and demonstrate genetically that Par-1 is required for accumulation of Osk protein. We show in cell-free extracts that Osk protein is intrinsically unstable and that it is stabilized after phosphorylation by Par-1. Our data indicate that posteriorly localized Par-1 regulates posterior patterning by stabilizing Osk.

[Indexed for MEDLINE]

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