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J Cell Sci. 2002 Apr 15;115(Pt 8):1567-74.

BH3-only proteins - evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death.

Author information

1
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia. bouillet@wehi.edu

Abstract

The BH3-only members of the Bcl-2 protein family are essential initiators of programmed cell death and are required for apoptosis induced by cytotoxic stimuli. These proteins have evolved to recognise distinct forms of cell stress. In response, they unleash the apoptotic cascade by inactivating the protective function of the pro-survival members of the Bcl-2 family and by activating the Bax/Bax-like pro-apoptotic family members.

PMID:
11950875
[Indexed for MEDLINE]
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