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Curr Opin Biotechnol. 2002 Apr;13(2):104-10.

Directed evolution of enzymes and pathways for industrial biocatalysis.

Author information

1
Department of Chemical Engineering, Center for Biophysics and Computational Biology, University of Illinois, Urbana, IL 61801, USA. zhao5@uiuc.edu

Abstract

Directed evolution has become a powerful tool for developing enzyme and whole cell based biocatalysts. Significant recent advances include the creation of novel enzyme functions and the development of several new efficient directed evolution methods. The combination of directed evolution and rational design promises to accelerate the development of biocatalysts for applications in the pharmaceutical, chemical and food industries.

PMID:
11950559
DOI:
10.1016/s0958-1669(02)00291-4
[Indexed for MEDLINE]

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