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Biochem J. 2002 Jul 1;365(Pt 1):223-8.

Activation of glucokinase gene expression by hepatic nuclear factor 4alpha in primary hepatocytes.

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1
Institut für Biochemie und Molekulare Zellbiologie, Georg-August-Universität Göttingen, Humboldtallee 23, D-37073 Göttingen, Germany.

Abstract

Glucokinase (GK) is a key enzyme for glucose utilization in liver and shows a higher expression in the perivenous zone. In primary rat hepatocytes, the GK gene expression was activated by HNF (hepatic nuclear factor)-4alpha via the sequence -52/-39 of the GK promoter. Venous pO2 enhanced HNF-4 levels and HNF-4 binding to the GK-HNF-4 element. Thus, HNF-4alpha could play the role of a regulator for zonated GK expression.

PMID:
11950391
PMCID:
PMC1222650
DOI:
10.1042/BJ20020340
[Indexed for MEDLINE]
Free PMC Article
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