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Mutat Res. 2002 Apr 26;516(1-2):57-61.

Should gaps be included in chromosomal aberration analysis? Evidence based on the comet assay.

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Laboratorio de Genética Molecular y Citogenética Humana, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas y Naturales, P.O. Box 17-1-2184, Quito, Ecuador.


This study evaluated DNA damage in human lymphocytes due to occupational exposure to low levels of ionizing radiation using two assays: the comet assay and chromosomal aberration (CA) analysis including and excluding gaps. The results obtained reveal a higher correlation between both methods when chromatid and chromosome gaps were included in the correlation analysis (r=0.78 versus r=0.50). This increased correlation support the hypothesis that the gaps constitute a type of chromosome aberration, and suggest that these events should be scored in this type of analysis.

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