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Convuls Ther. 1985;1(3):173-182.

Relative Efficacy Rates for Therapies of Delusional Depression.

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Department of Psychiatry and Behavioral Science, School of Medicine, State University of New York at Stony Brook, Stony Brook, New York, USA.


The treatment responses of 597 patients with delusional depression from 17 studies were compared. Patients were treated with either tricyclic anti-depressants (TCAs), antipsychotics (APs), the combination of TCA/AP, or electroconvulsive therapy (ECT). The overall responses were 34% in the group treated with TCA, 51% in the AP group, 77% in the TCA/AP group, and 82% in the ECT group. Prospective studies to define the risk/benefit ratios of the more effective therapies, TCA/AP and ECT, are needed.

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