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Arch Neurol. 2002 Apr;59(4):637-9.

Abnormal diffusion-weighted magnetic resonance imaging in Creutzfeldt-Jakob disease following corneal transplantations.

Author information

1
University of Miami School of Medicine D4-5, PO Box 016960, Miami, FL 33101, USA. alerabas@yahoo.com

Abstract

BACKGROUND:

The value of magnetic resonance imaging of the brain in the diagnosis of iatrogenic cases of Creutzfeldt-Jakob disease has been questioned.

OBJECTIVE:

To illustrate the value of magnetic resonance imaging of the brain in the diagnosis of iatrogenic Creutzfeldt-Jakob disease.

METHODS:

Case report.

RESULTS:

A patient with a history of 3 corneal transplantations exhibited the alien hand sign on initial examination. Diffusion-weighted magnetic resonance imaging of the brain revealed prominent cortical diffusion abnormalities. During the following months, the patient developed rapidly progressive dementia. The diagnosis of Creutzfeldt-Jakob disease was proven by brain biopsy.

CONCLUSION:

Brain magnetic resonance imaging, particularly diffusion-weighted magnetic resonance imaging, can be very helpful in the diagnosis of Creutzfeldt-Jakob disease, even in suspected iatrogenic cases.

PMID:
11939901
[Indexed for MEDLINE]

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