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Genes Dev. 2002 Apr 1;16(7):836-45.

The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding.

Author information

1
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

Abstract

The small GTPase Rac has been implicated in growth cone guidance mediated by semaphorins and their receptors. Here we demonstrate that plexin-B1, a receptor for Semaphorin4D (Sema4D), and p21-activated kinase (PAK) can compete for the interaction with active Rac and plexin-B1 can inhibit Rac-induced PAK activation. We have also demonstrated that expression of active Rac enhances the ability of plexin-B1 to interact with Sema4D. Active Rac stimulates the localization of plexin-B1 to the cell surface. The enhancement in Sema4D binding depends on the ability of Rac to bind plexin-B1. These observations support a model where signaling between Rac and plexin-B1 is bidirectional; Rac modulates plexin-B1 activity and plexin-B1 modulates Rac function.

PMID:
11937491
PMCID:
PMC186329
DOI:
10.1101/gad.966402
[Indexed for MEDLINE]
Free PMC Article
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