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Bioorg Med Chem. 2002 Jun;10(6):1813-8.

Efficient and highly stereoselective synthesis of a beta-lactam inhibitor of the serine protease prostate-specific antigen.

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Centro CNR and Dipartimento di Chimica Organica e Industriale, Universita' degli Studi di Milano, Via Golgi 19, I-20133, Milan, Italy.


An efficient synthesis of a beta-lactam precursor of the serine protease, prostate-specific antigen inhibitor 1 has been accomplished. The synthesis relies on two completely stereoselective reactions that allow the introduction of the stereocenters at C-3 and C-4 of the azetidinone ring in a predictable manner.

[Indexed for MEDLINE]

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