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Bioorg Med Chem. 2002 Jun;10(6):1711-7.

Metabolites of orally active NO-independent pyrazolopyridine stimulators of soluble guanylate cyclase.

Author information

1
Institute of Medicinal Chemistry, Pharma Research Centre, Bayer AG, D-42096, Wuppertal, Germany. alexander.straub.as@bayer-ag.de

Erratum in

  • Bioorg Med Chem. 2002 Sep;10(9):3075.

Abstract

The pyrazolopyridine stimulators of soluble guanylate cyclase BAY 41-2272 and 41-8543 were oxidised in rats and dogs at their 5-pyrimidinyl-cyclopropyl and -morpholino residue. These metabolites activate the soluble guanylate cyclase, induce vasoelaxation and thereby may contribute to the in vivo activity of BAY 41-2272 and BAY 41-8543.

PMID:
11937330
DOI:
10.1016/s0968-0896(02)00034-2
[Indexed for MEDLINE]

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