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Curr Biol. 2002 Apr 2;12(7):606-8.

Functional integration of adult-born neurons.

Author information

1
Department of Cell and Molecular Biology, Medical Nobel Institute, Stockholm, Sweden.

Abstract

Over the past decade, it has become clear that neural stem cells in the adult mammalian brain continuously generate new neurons, predominantly in the hippocampus and olfactory bulb. However, the central issue of whether these new neurons participate in functional synaptic circuitry has yet to be resolved. Here, we use virus-based transsynaptic neuronal tracing and c-Fos mapping of odor-induced neuronal activity to demonstrate that neurons generated in the adult functionally integrate into the synaptic circuitry of the brain.

PMID:
11937032
DOI:
10.1016/s0960-9822(02)00771-6
[Indexed for MEDLINE]
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