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Rheumatology (Oxford). 2002 Mar;41(3):285-9.

Bioavailable testosterone in men with rheumatoid arthritis-high frequency of hypogonadism.

Author information

1
Department of Rheumatology, Karolinska Institutet at Huddinge University Hospital, 141 86 Stockholm, Sweden.

Abstract

OBJECTIVES:

To study bioavailable testosterone (T) in men with rheumatoid arthritis (RA) by determining non-sex hormone-binding globulin (SHBG)-bound T (NST) under standardized conditions and to investigate if NST is related to disease variables.

METHODS:

Basal serum concentrations of total T, SHBG and luteinizing hormone (LH) were measured in 104 men with RA, and the levels of NST as well as the quotient T/SHBG were calculated. The data were compared with those of 99 age-matched healthy men. The results were analysed separately for the age groups 30-49, 50-59 and 60-69 yr.

RESULTS:

The RA men had lower NST levels than the healthy men in all age groups. T levels and the T/SHBG ratio were lower only in the age group 50-59 yr. SHBG did not differ significantly. LH was significantly lower in the patients than in the controls. Thirty-three of the 104 patients were considered to have hypogonadism compared with seven of the 99 healthy men. The only clinical variable apart from age that had a significant impact on NST was the Stanford Health Assessment Questionnaire (HAQ).

CONCLUSION:

Men with RA had lower levels of bioavailable T and a large proportion were considered hypogonadal. The low levels of LH suggested a central origin of the relative hypoandrogenicity.

PMID:
11934965
[Indexed for MEDLINE]

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