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Curr Opin Microbiol. 2002 Apr;5(2):202-5.

Phospholipid modifications in bacteria.

Author information

1
Department of Microbiology, University of Illinois, B103 Chemical and Life Sciences Laboratory, 601 South Goodwin Avenue, Urbana, Illinois 61801, USA. j-cronan@life.uiuc.edu

Abstract

Many bacteria alter the acyl chains of their membrane phospholipids in response to changing environmental conditions. Two of these modifications are reviewed: cis-->trans isomerization and cyclopropanation of double bonds. The isomerization reaction is now known to be catalyzed by a periplasmic protein that contains a covalently bound heme. Cyclopropanation has been shown to play a role in Mycobacterium tuberculosis pathogenesis and, in Escherichia coli, plays an important role in resistance to acidic conditions.

PMID:
11934618
[Indexed for MEDLINE]

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