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Curr Opin Microbiol. 2002 Apr;5(2):202-5.

Phospholipid modifications in bacteria.

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Department of Microbiology, University of Illinois, B103 Chemical and Life Sciences Laboratory, 601 South Goodwin Avenue, Urbana, Illinois 61801, USA.


Many bacteria alter the acyl chains of their membrane phospholipids in response to changing environmental conditions. Two of these modifications are reviewed: cis-->trans isomerization and cyclopropanation of double bonds. The isomerization reaction is now known to be catalyzed by a periplasmic protein that contains a covalently bound heme. Cyclopropanation has been shown to play a role in Mycobacterium tuberculosis pathogenesis and, in Escherichia coli, plays an important role in resistance to acidic conditions.

[Indexed for MEDLINE]

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