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Nature. 2002 Apr 4;416(6880):499-506.

An extensive network of coupling among gene expression machines.

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Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.


Gene expression in eukaryotes requires several multi-component cellular machines. Each machine carries out a separate step in the gene expression pathway, which includes transcription, several pre-messenger RNA processing steps and the export of mature mRNA to the cytoplasm. Recent studies lead to the view that, in contrast to a simple linear assembly line, a complex and extensively coupled network has evolved to coordinate the activities of the gene expression machines. The extensive coupling is consistent with a model in which the machines are tethered to each other to form 'gene expression factories' that maximize the efficiency and specificity of each step in gene expression.

[Indexed for MEDLINE]

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