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Trends Genet. 2002 Apr;18(4):165-7.

Near the edge of a chromosome's "black hole".

Author information

1
Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA. steveh@fhcrc.org

Abstract

The inability of current technology to determine contiguous sequence for highly repetitive regions means that centromeres fall within multi-megabase gaps, analogous to black holes from which no information escapes. However, high-resolution mapping of a human X-centromere border reveals a remarkable structure, including a gradient of alpha-satellite divergence up to the edge of the youngest and most homogeneous repeats.

PMID:
11932007
DOI:
10.1016/s0168-9525(01)02622-1
[Indexed for MEDLINE]

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