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Mol Cell. 2002 Mar;9(3):459-70.

Mechanisms of caspase activation and inhibition during apoptosis.

Author information

1
Department of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Washington Road, Princeton, NJ 08544, USA. yshi@molbio.princeton.edu

Abstract

Caspases are central components of the machinery responsible for apoptosis. Recent structural and biochemical studies on procaspases, IAPs, Smac/DIABLO, and apoptosome have revealed a conserved mechanism of caspase activation and inhibition. This article reviews these latest advances and presents our current understanding of caspase regulation during apoptosis.

PMID:
11931755
DOI:
10.1016/s1097-2765(02)00482-3
[Indexed for MEDLINE]
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