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Neuron. 2002 Mar 28;34(1):1-2.

Getting a GRIP on liprins.

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Department of Molecular, Cell & Developmental Biology, University of California-Santa Cruz, Santa Cruz, CA 95064, USA.


Two papers in this issue of Neuron add a new dimension to our understanding of liprin and LAR RPTP function during synapse formation. present evidence that Dliprin-alpha interacts with Dlar to regulate presynaptic morphogenesis of the Drosophila neuromuscular junction. demonstrate that mammalian liprin-alpha1 forms a complex with the PDZ protein GRIP and LAR in both pre- and postsynaptic compartments of hippocampal neurons and is required for the clustering of the GluR2 glutamate receptor in dendritic spines.

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