Format

Send to

Choose Destination
Hum Biol. 2002 Feb;74(1):11-23.

Segregation analysis of blood pressure and body mass index in a rural US community.

Author information

1
Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, USA.

Abstract

To assess evidence for a gene with large effect on systolic blood pressure (SBP), diastolic blood pressure (DBP), and body mass index (BMI), we conducted segregation analyses on 261 nuclear families collected from a rural Caucasian community in Michigan. The families were ascertained through a hypertensive proband. Each phenotype was adjusted for significant covariate effects (e.g., gender and age). We used class D regressive models to conduct the segregation analyses. Our analysis results support the segregation of a major gene for BMI, but not for SBP or DBP. A recessive locus effect provided the best explanation for BMI where approximately 43% of the variance of BMI was due to this gene.

PMID:
11931572
DOI:
10.1353/hub.2002.0010
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center